Followill, who describes himself as a "germophobe," said there was already poop on his pedal and carpet when he walked out on stage.
The aerial attack began during the opening song -- "Closer" -- when he was bombed in the face. His bass tech wiped most of it off with a sanitary wipe, he said.
Excrement struck each of his arms over the next two numbers, he said.
Opening bands The Postelles and The Stills came offstage complaining of getting riddled with large amounts of excrement, their publicist said.
"The Kings of Leon decided to carry on regardless," they said in a statement released Saturday. "The band felt it would be unfair to the fans to cancel the show at that late moment."
"We couldn't believe what The Postelles and The Stills looked like after their sets," Followill said. "We didn't want to cancel the show, so we went for it. We tried to play. It was ridiculous."
Concertgoers were apparently spared the aerial bombardment.
"No fans got pooped on as far as we know," the band's publicist said.