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Thread: 1918 flu survivors share memories as research continues

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    1918 flu survivors share memories as research continues




    Roy Braswell was 9 years old when the flu pandemic of 1918 hit.

    Margaret Duchez, 94, sees some similarities to the 1918 situation, like the dozens of school closings.

    "I know it's a bad feeling, 'cause I had it," said Braswell, 100, who now lives in Cobb County in Georgia. "It makes you have headaches, you be out of your head, you don't know nothing."

    Margaret Duchez, 94, did not have the flu, but remembers that in 1918 her grandmother locked the door so that she couldn't go outside during the pandemic. In her community near Cleveland, Ohio, people were afraid to go to church, walk in the street or let children play outside, she said. An entire family died around the corner from her.

    "People were dying so fast in our parish, which was old St. Patrick's, they could not bury them fast enough," Duchez said.

    A study in Nature last year showed survivors of the 1918 pandemic still have some immunity to that virus in the form of B cells, which are immune cells that produce antibodies.

    Now, researchers are taking the knowledge from that study to work toward an antibody treatment for swine flu, the 2009 H1N1 virus that has sickened hundreds of people worldwide.

    When a person gets infected with a virus, the body typically mounts an immune response to it. B cells produce antibodies, leaving the person at least partially immune to the disease, said Dr. James Crowe, professor at Vanderbilt University and lead study author.

    The levels of immune response tend to wane with time, he said. The response is strongest within the first several months, and then diminishes over the following years.

    In the Nature study, supported by the National Institutes of Health, Crowe and colleagues took these rare B cells from survivors' blood and cloned the antibody genes from these cells to produce antibodies in the laboratory.

    "It's interesting because we had this technology, and we should be able to do this with survivors of any flu," he said.

    Applying this technique to the 2009 H1N1 virus, researchers could use blood from swine flu survivors to develop an antibody molecule, which is "a biologic drug that we could give to people to protect them against the current swine flu, or possibly to treat them," he said.

    Crowe said he was shocked to find B cells that produce 1918 flu antibodies from the blood of flu survivor volunteers 90 years after they got the illness.

    "Typically, it's thought that you have high levels of antibodies for about 10 years," he said. "Our studies have shown in some cases you keep antibodies for the rest of your life.

    Crowe and collaborators are now in the process of working with the Centers for Disease Control and Prevention to get blood samples of survivors of 2009 H1N1.
    If a survivor of a virus maintains immunity for years, does this mean people should try to contract a mild case of a virus so that they will naturally develop antibodies? This used to be the logic with chicken pox, a far more serious illness for adults than children. Before there was a vaccine, people thought children ought to catch the disease to avoid complications later in life, he said.

    But Crowe does not advise that anyone purposely contract swine flu to develop immunity, even in the United States, where most cases appear mild.

    "We don't know yet how severe this virus is going to be," he said.

    Duchez, who follows the news on television from her assisted living community in Westlake, Ohio, sees some similarities to the 1918 situation -- for example, the dozens of school closings nationwide.
    Still, the swine flu does not seem as bad, she said. Duchez recalls that when she went to school at age 6, in 1920, the nuns told of how they became nurses and put sulfur in their shoes to protect themselves from catching diseases.
    http://www.cnn.com/2009/HEALTH/05/04...ies/index.html
    Last edited by RaVen Blackehart; May 4th, 2009 at 06:59 PM.

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    Survivor relishes triumph over 1918 Spanish flu

    Mother credited with defying doctor



    FORT ERIE, Ont.—The prognosis was dire. Doctors told 5-year-old Donald Jacobi’s family that he would be dead by the next morning, another victim of the Spanish flu that, starting in 1918, killed 50 million people.

    Authorities wouldn’t even let the severely ill young Donald into the old Meyer Hospital — since replaced with Erie County Medical Center. Instead, he was dispatched to the “pest house” behind the hospital, where flu sufferers were sent to die.

    “What are you going to do for him?” his persistent mother, Magdalena — all 4-foot-11 of her — asked the doctor at the hospital.

    “There’s nothing we can do for him, because he’ll be dead by morning,” the doctor replied.

    His family wasn’t even allowed to take him home to die. The law said he had to remain in the “pest house,” to be fully quarantined.

    But you couldn’t tell that to Magdalena Jacobi. She then uttered the punch line that’s been passed down through the generations of the large Jacobi clan:

    “If he’s going to die, he’s going to die at home.”

    So the family bundled up young Donald G. Jacobi— there were no car heaters in those days — and took him back to South Buffalo, where he lay unconscious for about seven days. And then recovered.

    Jacobi, now 96, lived through perhaps the worst flu in history, a pandemic that killed three times as many people as died in World War I.

    The healthy, pain-free Jacobi now lives in a Fort Erie retirement home, where he still loves telling stories.

    There are no short interviews with Donald Jacobi, but he doesn’t have much to say about the current swine flu epidemic.

    “The only thing I can say is to keep breathing and don’t fall down,” he said. “And the greatest thing in the world is rest.”

    For a man who has lived more than 90 years past his doctor’s 1918 prediction, Jacobi is surprising in his assessment that people should listen to what health experts say about preventing the flu.

    “If anyone second-guesses the medical profession, I think they’re stupid,” Jacobi said during an hourlong interview in the Garrison Place retirement home on Garrison Road.

    As a first-grader at St. John the Evangelist School, he came home one day in the fall of 1918 saying he didn’t feel well.

    Young Donald was given the treatment of the day: drink a “hot whisky sling” — a shot of whisky with some hot water — and get under the covers of his feather bed.

    A Dr. Hurley—no one in the family knows his first name — twice came over to the family home on Indian Orchard Place. On the second visit, he advised the family to take Donald to the hospital.

    So his brother Norman drove the family’s nine-passenger touring car to the hospital, first picking up Father Hurd from St. John the Evangelist Church. The prognosis was so bad that Father Hurd promised to give Donald the “full shot,” both his First Communion and last rites.

    Norman carried his brother inside the pest house, where a nurse directed him to a cot.

    “The doctor came over, felt my head — I don’t remember any thermometer — and said, ‘He’s very serious. Most everybody in [here] will be dead by morning.’ ”

    “How about him?” Donald’s mother asked.

    “Including him,” the doctor replied.

    That’s when Magdalena stepped in, to pronounce that her son wasn’t going to be left in the pest house to die.

    Then Father Hurd, whom Jacobi remembers as a big guy, stepped in.

    “I wouldn’t argue with her,” he told the doctor. “She’s a very determined lady.”

    Mrs. Jacobi had ordered her son Norman to go to the car and retrieve the steamer rug. They wrapped the sick young child in the rug, let him lie down in the back seat on his mother’s lap and headed back to South Buffalo.

    Jacobi doesn’t remember the trip back home. He apparently lapsed into unconsciousness.

    His family knew all about epidemics. His older sister, Hortense, had died in the diphtheria epidemic a few months before Donald was born in 1913.

    So the family farmed out the other six children to relatives’ homes and set Donald up in the downstairs dining room. The family put a “Quarantine” sign on the door, and nobody was allowed to leave or enter. Some of his older brothers brought food and left it in the milk box.

    The treatment?

    “Every time I opened my mouth, I got butter soup,” Jacobi said.

    His father, Joe, later told him he gave his young son a hot whisky sling every night so he could sleep.

    “I’ve been sober ever since,” he said.

    On about the seventh day, young Donald looked out the window and saw his friend, Rabbit-Ear Wolley—named for his acute hearing, not the size of his ears—throwing snow at the window, trying to get his attention. It worked.

    The family summoned Dr. Hurley, who promptly drained the lymph glands under Donald’s jaw. His brother Frank told him that the doctor put in monkey glands.

    “I believed him,” he said.

    Jacobi went on to St. Joseph’s Collegiate Institute — at its former home on Main Street, near the current Delta Sonic car wash — a postgraduate year at Bennett High School and then the University of Notre Dame, where he now serves as class secretary for the class of 1935. Then came a long career in the clothing business, mostly with Jacobi Brothers and Don Jacobi Inc.
    video at link:

    http://www.buffalonews.com/cityregion/story/663658.html

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